Linking Micronuclei to Chromosome Fragmentation
نویسندگان
چکیده
Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei frequently undergo chromothripsis-like rearrangements in the subsequent cell cycle.
منابع مشابه
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عنوان ژورنال:
- Cell
دوره 161 شماره
صفحات -
تاریخ انتشار 2015